Projects Overview

Projects led by the group

Graphical Abstract:

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Abstract:

There still exist knowledge gaps regarding the perspective of resorbable magnesium implants that dissolve completely in the body. Although the instrumentation capabilities for materials testing are constantly evolving, there is not enough attention paid to mimicking the human body environment. This results in the overuse of experimental animals even for proof of concepts that could be confirmed or refuted in vitro. Furthermore, prominent problems connected with Mg implants are often overlooked, such as static vs. dynamic test conditions, hydrogen generation, corrosion localization, corrosion product redeposition, and the effects of sterilization and storage. The project aims to use dynamic mechanical analysis (DMA), together with a flow-through bioreactor to elucidate fundamental aspects of in vitro degradation. Moreover, in vitro-in vivo correlation factors and advanced polymer-based and composite protective coatings will be studied to address other pressing issues of these implants while providing a way for surface functionalization, including localized drug elution.

Project Aims:

(1) Design of functional coatings of Mg-based implants. (2) Determining the barriers affecting in vitro-in vivo correlation factors. (3) Comparison of static and dynamic loading of implants in simulated body media. (4) Studying the effects of storage and sterilization on Mg implants.

Abstract:

Biomedical implants have become increasingly important in addressing various medical conditions. Biodegradable implants, particularly those based on magnesium (Mg), zinc (Zn), and iron (Fe), show promising potential. However, challenges associated with metallic implants include achieving a uniform degradation rate, managing high corrosion rates, and preventing the formation of hydrogen bubbles. Supported by the Marie Skłodowska-Curie Actions (MSCA) programme, the AIDDRI project aims to address these challenges by developing an AI-based methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications. The results are expected to provide innovative Mg alloys with excellent performance, particularly in bone-support applications.

Abstract:

The aim of this project is to secure funding for the development of research on the corrosion behavior of biodegradable magnesium and zinc-based alloys, which are particularly suitable for medical implants. These alloys are highly attractive due to their low toxicity and natural degradation in the human body, eliminating the need for secondary surgical procedures. A critical aspect of their application is the detailed study of corrosion phenomena in body fluids and the specific conditions of the human body, including the impact of corrosion on the mechanical properties of implants. The project aims to develop advanced testing methodologies and evaluation techniques for magnesium and zinc alloys under these conditions, contributing to their safe and effective use in medical applications.
 

Projects we take part in

Project goals:

The FerrMion project aims to capture the complex behaviour of ferroic materials through a wide range of disciplines and then use the knowledge gained to design advanced applications of these materials, making their unique functional properties available to industry. Bridging the barrier between basic research and application design will enable the enormous potential of ferroic materials to be exploited for new, energy-efficient, sustainable and environmentally friendly technologies.